|Application ||WB, E|
|Other Accession||Q91ZU0, Q9BGT9, NP_078984.2|
|Calculated MW||36011 Da|
|Antigen Region||82-108 aa|
|Other Names||Ankyrin repeat and SOCS box protein 7, ASB-7, ASB7|
|Target/Specificity||This ASB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the Central region of human ASB7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASB7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq].
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
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