|Application ||WB, E|
|Calculated MW||34083 Da|
|Antigen Region||40-67 aa|
|Other Names||Iron-sulfur protein NUBPL, IND1 homolog, Nucleotide-binding protein-like, huInd1, NUBPL, C14orf127|
|Target/Specificity||This NUBPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-67 amino acids from the N-terminal region of human NUBPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUBPL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.|
|Tissue Location||Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Respiratory complex I (NADH:ubiquinone oxidoreductase EC 184.108.40.206) is a large mitochondrial inner membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters. NUBPL, or IND1, is an Fe/ S protein that plays a critical role in the assembly of respiratory complex I, likely by transferring Fe/S into the Fe/S-containing complex I subunits (Sheftel et al., 2009 [PubMed 19752196]).
Calvo, S.E., et al. Nat. Genet. 42(10):851-858(2010)
Sheftel, A.D., et al. Mol. Cell. Biol. 29(22):6059-6073(2009)
Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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