|Application ||WB, E|
|Calculated MW||61907 Da|
|Antigen Region||365-392 aa|
|Other Names||Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like, NPNT, EGFL6L, POEM|
|Target/Specificity||This NPNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from the Central region of human NPNT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NPNT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix.|
|Tissue Location||Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.|
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Provided below are standard protocols that you may find useful for product applications.
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
Kahai, S., et al. PLoS ONE 4 (10), E7535 (2009) :
Huang, J.T., et al. Int. J. Mol. Med. 15(4):719-724(2005)
Brandenberger, R., et al. J. Cell Biol. 154(2):447-458(2001)
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