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NPNT Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NPNT Antibody (Center) AP18069c
    NPNT Antibody (Center) (Cat. #AP18069c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the NPNT antibody detected the NPNT protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6UXI9
Other Accession NP_001028219.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61907 Da
Antigen Region 365-392 aa
Additional Information
Gene ID 255743
Other Names Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like, NPNT, EGFL6L, POEM
Target/Specificity This NPNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from the Central region of human NPNT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNPNT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPNT
Synonyms EGFL6L, POEM
Function Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Cellular Location Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix.
Tissue Location Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
Research Areas
Citations (0)

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Background

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

References

Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
Kahai, S., et al. PLoS ONE 4 (10), E7535 (2009) :
Huang, J.T., et al. Int. J. Mol. Med. 15(4):719-724(2005)
Brandenberger, R., et al. J. Cell Biol. 154(2):447-458(2001)

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Cat# AP18069c
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(40 western blots)
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