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FNDC4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H6D8 |
| Other Accession | A6QPL2, NP_073734.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25159 Da |
| Antigen Region | 202-228 aa |
| Gene ID | 64838 |
|---|---|
| Other Names | Fibronectin type III domain-containing protein 4, Fibronectin type III repeat-containing protein 1, FNDC4, FRCP1 |
| Target/Specificity | This FNDC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-228 amino acids from the C-terminal region of human FNDC4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FNDC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FNDC4 |
|---|---|
| Synonyms | FRCP1 |
| Function | Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:Q3TR08}. Note=The N-terminus is probably cleaved to release a secreted extracellular portion of the protein {ECO:0000250|UniProtKB:Q3TR08} |
| Tissue Location | Up-regulated in colon cells of patients with inflammatory bowel disease (IBD). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FNDC4 contains a fibronectin type-III (FN3) domain. FN3 repeats have been found in various protein families including extracellular-matrix molecules, cell-surface receptors, enzymes, and muscle proteins. The function of FNDC4 is unknown.
References
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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