NDST4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H3R1 |
Other Accession | NP_072091.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 100716 Da |
Antigen Region | 185-212 aa |
Gene ID | 64579 |
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Other Names | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, NDST-4, N-heparan sulfate sulfotransferase 4, N-HSST 4, Heparan sulfate N-deacetylase 4, 3---, Heparan sulfate N-sulfotransferase 4, 282-, NDST4, HSST4 |
Target/Specificity | This NDST4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-212 amino acids from the N-terminal region of human NDST4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NDST4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NDST4 |
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Synonyms | HSST4 |
Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Treutlein, J., et al. Arch. Gen. Psychiatry 66(7):773-784(2009)
Aikawa, J., et al. J. Biol. Chem. 276(8):5876-5882(2001)
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