|Application ||WB, E|
|Other Accession||P83858, P83861, NP_937822.2|
|Calculated MW||49488 Da|
|Antigen Region||172-198 aa|
|Other Names||Pyroglutamylated RFamide peptide receptor, AQ27, G-protein coupled receptor 103, Orexigenic neuropeptide QRFP receptor, SP9155, QRFPR, GPR103|
|Target/Specificity||This QRFPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-198 amino acids from the Central region of human QRFPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||QRFPR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Mulumba, M., et al. Mol. Endocrinol. 24(8):1615-1625(2010)
Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
Takayasu, S., et al. Proc. Natl. Acad. Sci. U.S.A. 103(19):7438-7443(2006)
Fukusumi, S., et al. J. Biol. Chem. 278(47):46387-46395(2003)
Jiang, Y., et al. J. Biol. Chem. 278(30):27652-27657(2003)
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