|Application ||WB, E|
|Calculated MW||131151 Da|
|Antigen Region||47-76 aa|
|Other Names||Dentin sialophosphoprotein, Dentin phosphoprotein, Dentin phosphophoryn, DPP, Dentin sialoprotein, DSP, DSPP|
|Target/Specificity||This DSPP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the N-terminal region of human DSPP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSPP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq].
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Bai, H., et al. BMC Med. Genet. 11, 23 (2010) :
Kida, M., et al. Eur. J. Oral Sci. 117(6):691-694(2009)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Qu, E.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(5):536-538(2009)
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