|Application ||WB, E|
|Other Accession||Q9BGS7, NP_001008229.1|
|Calculated MW||28193 Da|
|Antigen Region||82-109 aa|
|Other Names||Myelin-oligodendrocyte glycoprotein, MOG|
|Target/Specificity||This MOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-109 amino acids from the Central region of human MOG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.|
|Cellular Location||Isoform 1: Cell membrane; Multi-pass membrane protein Isoform 2: Cell membrane; Single-pass type I membrane protein Isoform 4: Cell membrane; Single-pass type I membrane protein Isoform 7: Cell membrane; Single-pass type I membrane protein Isoform 9: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Boyle, L.H., et al. J. Neurochem. 102(6):1853-1862(2007)
Allamargot, C., et al. J. Neurochem. 101(2):298-312(2007)
Delarasse, C., et al. J. Neurochem. 98(6):1707-1717(2006)
Ballenthin, P.A., et al. J. Neurosci. Res. 46(2):271-281(1996)
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