|Application ||WB, E|
|Other Accession||Q8CFH6, NP_056006.1|
|Calculated MW||103915 Da|
|Antigen Region||332-358 aa|
|Other Names||Serine/threonine-protein kinase SIK2, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2|
|Target/Specificity||This SIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-358 amino acids from the Central region of human SIK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Ahmed, A.A., et al. Cancer Cell 18(2):109-121(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nagel, S., et al. Leuk. Lymphoma 51(5):881-891(2010)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Katoh, Y., et al. Eur. J. Biochem. 271(21):4307-4319(2004)
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