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SIK2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SIK2 Antibody (Center) AP18127c
    SIK2 Antibody (Center) (Cat. #AP18127c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SIK2 antibody detected the SIK2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H0K1
Other Accession Q8CFH6, NP_056006.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 103915 Da
Antigen Region 332-358 aa
Additional Information
Gene ID 23235
Other Names Serine/threonine-protein kinase SIK2, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2
Target/Specificity This SIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-358 amino acids from the Central region of human SIK2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIK2
Function Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

References

Ahmed, A.A., et al. Cancer Cell 18(2):109-121(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nagel, S., et al. Leuk. Lymphoma 51(5):881-891(2010)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Katoh, Y., et al. Eur. J. Biochem. 271(21):4307-4319(2004)

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$ 295.00
$ 99.00
Cat# AP18127c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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