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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NOG Antibody (Center)   

NOG Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NOG Antibody (Center) AP18131c
    Anti-NOG Antibody (Center) at 1:1000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 26 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - NOG Antibody (Center) AP18131c
    NOG Antibody (Center) (Cat. #AP18131c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NOG antibody detected the NOG protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13253
Other Accession Q62809, P97466, NP_005441.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25774 Da
Antigen Region 84-111 aa
Additional Information
Gene ID 9241
Other Names Noggin, NOG
Target/Specificity This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNOG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOG
Function Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273).
Cellular Location Secreted.
Research Areas
Citations (0)

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The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.


Rudnik-Schoneborn, S., et al. Am. J. Med. Genet. A 152A (6), 1540-1544 (2010) :
Song, K., et al. J. Biol. Chem. 285(16):12169-12180(2010)
Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)
Gutierrez, S.J., et al. Acta Odontol Latinoam 23(1):13-19(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

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$ 295.00
$ 99.00
Cat# AP18131c
(40 western blots)
Availability: In Stock
Bulk Size
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