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FIG4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FIG4 Antibody (C-term) AP18145b
    FIG4 Antibody (C-term) (Cat. #AP18145b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FIG4 antibody detected the FIG4 protein (arrow).
  • WB - FIG4 Antibody (C-term) AP18145b
    FIG4 Antibody (C-term) (Cat. #AP18145b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the FIG4 antibody detected the FIG4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92562
Other Accession Q91WF7, NP_055660.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 103635 Da
Antigen Region 846-874 aa
Additional Information
Gene ID 9896
Other Names Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3, 5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3
Target/Specificity This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFIG4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FIG4
Synonyms KIAA0274, SAC3
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Cellular Location Endosome membrane. Note=Localization requires VAC14 and PIKFYVE
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.


Ikonomov, O.C., et al. J. Biol. Chem. 285(35):26760-26764(2010)
Tsai, C.P., et al. Neurobiol. Aging (2010) In press :
Ikonomov, O.C., et al. J. Biol. Chem. 284(51):35794-35806(2009)
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)
Trynka, G., et al. Gut 58(8):1078-1083(2009)

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Cat# AP18145b
(40 western blots)
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