|Application ||WB, IF, E|
|Other Accession||P22605, P22448, NP_000956.2|
|Calculated MW||50489 Da|
|Antigen Region||168-195 aa|
|Other Names||Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, RARB, HAP, NR1B2|
|Target/Specificity||This RARB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the Central region of human RARB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RARB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.|
|Cellular Location||Isoform Beta-1: Nucleus. Isoform Beta-4: Cytoplasm.|
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This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Miladi-Abdennadher, I., et al. Tumour Biol. 31(5):503-511(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ding, Y., et al. Mol. Vis. 16, 855-861 (2010) :
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