|Application ||WB, E|
|Calculated MW||128153 Da|
|Antigen Region||641-669 aa|
|Other Names||Nck-associated protein 1-like, Hematopoietic protein 1, Membrane-associated protein HEM-1, NCKAP1L, HEM1|
|Target/Specificity||This NCKPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-669 amino acids from the Central region of human NCKPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCKPL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Cytoplasmic side|
|Tissue Location||Expressed only in cells of hematopoietic origin|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.
Joshi, A.D., et al. Clin. Cancer Res. 13 (18 PT 1), 5295-5304 (2007) :
Weiner, O.D., et al. PLoS Biol. 5 (9), E221 (2007) :
Weiner, O.D., et al. PLoS Biol. 4 (2), E38 (2006) :
Baumgartner, S., et al. J. Mol. Biol. 251(1):41-49(1995)
Hromas, R., et al. Biochim. Biophys. Acta 1090(2):241-244(1991)
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