|Application ||WB, E|
|Other Accession||Q4V885, A6QP79, NP_569057.1|
|Calculated MW||81515 Da|
|Antigen Region||71-100 aa|
|Other Names||Collectin-12, Collectin placenta protein 1, CL-P1, hCL-P1, Nurse cell scavenger receptor 2, Scavenger receptor class A member 4, Scavenger receptor with C-type lectin, COLEC12, CLP1, NSR2, SCARA4, SRCL|
|Target/Specificity||This COL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human COL12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLP1, NSR2, SCARA4, SRCL|
|Function||Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface|
|Tissue Location||Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. In addition, these receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Liu, Y., et al. Mol. Psychiatry (2010) In press :
Samsen, A., et al. Eur. J. Cell Biol. 89(1):87-94(2010)
Jang, S., et al. J. Biol. Chem. 284(6):3956-3965(2009)
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