|Application ||WB, E|
|Calculated MW||32543 Da|
|Antigen Region||96-124 aa|
|Other Names||Valacyclovir hydrolase, VACVase, Valacyclovirase, 31--, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA|
|Target/Specificity||This BPHL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human BPHL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BPHL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.|
|Tissue Location||Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lai, L., et al. J. Biol. Chem. 283(14):9318-9327(2008)
Grigo, K., et al. Biol. Chem. 389(2):179-187(2008)
Melk, A., et al. Kidney Int. 68(6):2667-2679(2005)
Kim, I., et al. Mol. Pharm. 1(6):434-446(2004)
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