BPHL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q86WA6 |
Other Accession | NP_004323.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32543 Da |
Antigen Region | 96-124 aa |
Gene ID | 670 |
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Other Names | Valacyclovir hydrolase, VACVase, Valacyclovirase, 31--, Biphenyl hydrolase-like protein, Biphenyl hydrolase-related protein, Bph-rp, Breast epithelial mucin-associated antigen, MCNAA, BPHL, MCNAA |
Target/Specificity | This BPHL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human BPHL. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BPHL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BPHL |
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Synonyms | MCNAA |
Function | Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. |
Tissue Location | Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lai, L., et al. J. Biol. Chem. 283(14):9318-9327(2008)
Grigo, K., et al. Biol. Chem. 389(2):179-187(2008)
Melk, A., et al. Kidney Int. 68(6):2667-2679(2005)
Kim, I., et al. Mol. Pharm. 1(6):434-446(2004)
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