|Application ||WB, E|
|Calculated MW||45553 Da|
|Antigen Region||149-178 aa|
|Other Names||Pleckstrin homology domain-containing family A member 1, PH domain-containing family A member 1, Tandem PH domain-containing protein 1, TAPP-1, PLEKHA1, TAPP1|
|Target/Specificity||This PLEKHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human PLEKHA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLEKHA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2|
|Tissue Location||Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
Deangelis, M.M., et al. Ophthalmology 115(7):1209-1215(2008)
Manna, D., et al. J. Biol. Chem. 282(44):32093-32105(2007)
Kanda, A., et al. Proc. Natl. Acad. Sci. U.S.A. 104(41):16227-16232(2007)
Leveziel, N., et al. Mol. Vis. 13, 2153-2159 (2007) :
Hogan, A., et al. J. Biol. Chem. 279(51):53717-53724(2004)
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