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RNF217 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8TC41 |
| Other Accession | D3YYI7, NP_689766.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59372 Da |
| Antigen Region | 13-40 aa |
| Gene ID | 154214 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase RNF217, 632-, IBR domain-containing protein 1, RING finger protein 217, RNF217, C6orf172, IBRDC1 |
| Target/Specificity | This RNF217 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-40 amino acids from the N-terminal region of human RNF217. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNF217 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNF217 |
|---|---|
| Synonyms | C6orf172, IBRDC1, OSTL {ECO:0000303|PubM |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. |
| Cellular Location | Membrane; Single-pass membrane protein. Cytoplasm |
| Tissue Location | Mainly expressed in testis and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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