|Application ||WB, E|
|Calculated MW||160160 Da|
|Antigen Region||777-804 aa|
|Other Names||Kinesin-like protein KIF15, Kinesin-like protein 2, hKLP2, Kinesin-like protein 7, Serologically defined breast cancer antigen NY-BR-62, KIF15, KLP2, KNSL7|
|Target/Specificity||This KIF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 777-804 amino acids from the Central region of human KIF15.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF15 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis Localizes at the central spindle at anaphase (By similarity) Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity).|
|Tissue Location||Expressed in testis, colon, thymus and in breast cancer.|
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Provided below are standard protocols that you may find useful for product applications.
Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity).
Vanneste, D., et al. Curr. Biol. 19(20):1712-1717(2009)
Tanenbaum, M.E., et al. Curr. Biol. 19(20):1703-1711(2009)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Scanlan, M.J., et al. Cancer Immun. 1, 4 (2001) :
Sueishi, M., et al. J. Biol. Chem. 275(37):28888-28892(2000)
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