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ID3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ID3 Antibody (C-term) AP18321b
    ID3 Antibody (C-term) (Cat. #AP18321b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ID3 Antibody detected the ID3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02535
Other Accession NP_002158.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 12999 Da
Antigen Region 86-115 aa
Additional Information
Gene ID 3399
Other Names DNA-binding protein inhibitor ID-3, Class B basic helix-loop-helix protein 25, bHLHb25, Helix-loop-helix protein HEIR-1, ID-like protein inhibitor HLH 1R21, Inhibitor of DNA binding 3, Inhibitor of differentiation 3, ID3, 1R21, BHLHB25, HEIR1
Target/Specificity This ID3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the C-terminal region of human ID3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsID3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ID3
Synonyms 1R21, BHLHB25, HEIR1
Function Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Cellular Location Nucleus.
Tissue Location Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain
Research Areas
Citations (0)

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Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.


Shuno, Y., et al. J. Surg. Res. 161(1):76-82(2010)
Doran, A.C., et al. Circ. Res. 106(7):1303-1311(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Higgins, S., et al. Endocrinology 150(9):4044-4055(2009)
Trabosh, V.A., et al. Exp. Dermatol. 18(4):387-395(2009)

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$ 295.00
$ 99.00
Cat# AP18321b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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