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ZSCAN4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NAM6 |
| Other Accession | NP_689890.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48957 Da |
| Antigen Region | 94-120 aa |
| Gene ID | 201516 |
|---|---|
| Other Names | Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494, ZSCAN4, ZNF494 |
| Target/Specificity | This ZSCAN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-120 amino acids from the N-terminal region of human ZSCAN4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZSCAN4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZSCAN4 |
|---|---|
| Synonyms | ZNF494 |
| Function | Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Chromosome, telomere |
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Provided below are standard protocols that you may find useful for product applications.
Background
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).
References
Zalzman, M., et al. Nature 464(7290):858-863(2010)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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