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ABCC9 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60706 |
| Other Accession | NP_005682.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 174223 Da |
| Antigen Region | 640-669 aa |
| Gene ID | 10060 |
|---|---|
| Other Names | ATP-binding cassette sub-family C member 9, Sulfonylurea receptor 2, ABCC9, SUR2 |
| Target/Specificity | This ABCC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-669 amino acids from the Central region of human ABCC9. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ABCC9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ABCC9 |
|---|---|
| Synonyms | SUR2 {ECO:0000303|PubMed:31575858} |
| Function | Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. |
| Cellular Location | Membrane {ECO:0000255|PROSITE-ProRule:PRU00441}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Kim, S.J., et al. Biochem. Biophys. Res. Commun. 391(1):974-978(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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