|Application ||WB, E|
|Other Accession||Q4R4K2, NP_113620.1|
|Calculated MW||31435 Da|
|Antigen Region||231-260 aa|
|Other Names||Uridine-cytidine kinase 1, UCK 1, Cytidine monophosphokinase 1, Uridine monophosphokinase 1, UCK1, URK1|
|Target/Specificity||This UCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human UCK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UCK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.|
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Provided below are standard protocols that you may find useful for product applications.
Uridine/cytidine kinase-1 (EC 22.214.171.124) is a pyrimidine ribonucleoside kinase that catalyzes the phosphorylation of uridine and cytidine to form uridine monophosphate (UMP) and cytidine monophosphate (CMP) (Van Rompay et al., 2001 [PubMed 11306702]).
Virovic Jukic, L., et al. J. Biomed. Sci. 15(2):205-213(2008)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Van Rompay, A.R., et al. Mol. Pharmacol. 59(5):1181-1186(2001)
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