|Application ||WB, E|
|Calculated MW||21697 Da|
|Antigen Region||53-80 aa|
|Other Names||Protein SSX3, Cancer/testis antigen 53, CT53, SSX3|
|Target/Specificity||This SSX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-80 amino acids from the Central region of human SSX3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SSX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could act as a modulator of transcription.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of chromosome translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Gure, A.O., et al. Int. J. Cancer 101(5):448-453(2002)
de Bruijn, D.R., et al. Genes Chromosomes Cancer 34(3):285-298(2002)
Gure, A.O., et al. Int. J. Cancer 72(6):965-971(1997)
de Leeuw, B., et al. Cytogenet. Cell Genet. 73(3):179-183(1996)
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