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SEPSECS Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP18403b 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
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AP18403b-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
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SEPSECS Antibody (C-term) - Product info

Application
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ9HD40
Other AccessionNP_058651.3
ReactivityHuman
Isotype Rabbit Ig
Calculated MW 55726 Da

SEPSECS Antibody (C-term) - Additional info

Gene ID 51091
Other Names
SEPSECS; TRNP48; O-phosphoseryl-tRNA(Sec) selenium transferase; Liver-pancreas antigen; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; Soluble liver antigen; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
Target/Specificity
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
SEPSECS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.

SEPSECS Antibody (C-term) - Protein Information

Name SEPSECS
Synonyms TRNP48
Function
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.
Cellular Location
Cytoplasm.
Tissue Location
Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells

SEPSECS Antibody (C-term) - Related products

BP18403b: SEPSECS Antibody (C-term) Blocking Peptide

SEPSECS Antibody (C-term) - Research Areas

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).

REFERENCES

Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)
Hart, K., et al. Lung Cancer (2010) In press :
Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)
Palioura, S., et al. Science 325(5938):321-325(2009)
Xu, X.M., et al. PLoS Biol. 5 (1), E4 (2007) :