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SEPSECS Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP18403b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP18403b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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SEPSECS Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9HD40 |
| Other Accession | NP_058651.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 55726 Da |
SEPSECS Antibody (C-term) - Additional info | |
| Gene ID 51091 | |
| Other Names SEPSECS; TRNP48; O-phosphoseryl-tRNA(Sec) selenium transferase; Liver-pancreas antigen; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; Soluble liver antigen; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein | |
| Target/Specificity This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-474 amino acids from the C-terminal region of human SEPSECS. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SEPSECS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SEPSECS Antibody (C-term) - Protein Information | |
| Name SEPSECS | |
| Synonyms TRNP48 | |
| Function Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis | |
| Cellular Location Cytoplasm. | |
| Tissue Location Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells | |
SEPSECS Antibody (C-term) - Related products
SEPSECS Antibody (C-term) - Application data
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SEPSECS Antibody (C-term) (Cat. #AP18403b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SEPSECS Antibody detected the SEPSECS protein (arrow).
SEPSECS Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).
REFERENCES
Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010) Hart, K., et al. Lung Cancer (2010) In press : Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010) Palioura, S., et al. Science 325(5938):321-325(2009) Xu, X.M., et al. PLoS Biol. 5 (1), E4 (2007) :
