|Application ||WB, E|
|Calculated MW||55726 Da|
|Antigen Region||444-474 aa|
|Other Names||O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48|
|Target/Specificity||This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEPSECS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.|
|Tissue Location||Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells|
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Provided below are standard protocols that you may find useful for product applications.
The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).
Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)
Hart, K., et al. Lung Cancer (2010) In press :
Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)
Palioura, S., et al. Science 325(5938):321-325(2009)
Xu, X.M., et al. PLoS Biol. 5 (1), E4 (2007) :
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