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SLU7 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SLU7 Antibody (N-term) AP18404a
    SLU7 Antibody (N-term) (Cat. #AP18404a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SLU7 Antibody detected the SLU7 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95391
Other Accession Q3KQD1, Q80ZG5, Q8BHJ9, Q4R4P2, Q5U3F2, Q5ZIG2, Q3ZBE5, NP_006416.3
Reactivity Human
Predicted Bovine, Chicken, Zebrafish, Monkey, Mouse, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68387 Da
Antigen Region 60-86 aa
Additional Information
Gene ID 10569
Other Names Pre-mRNA-splicing factor SLU7, hSlu7, SLU7
Target/Specificity This SLU7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-86 amino acids from the N-terminal region of human SLU7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLU7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLU7
Function Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules
Research Areas
Citations (0)

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Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq].


Alberstein, M., et al. RNA 13(11):1988-1999(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Shomron, N., et al. J. Cell. Sci. 118 (PT 6), 1151-1159 (2005) :
Shomron, N., et al. Mol. Biol. Cell 15(8):3782-3795(2004)
Chua, K., et al. Mol. Cell. Biol. 21(5):1509-1514(2001)

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$ 295.00
$ 99.00
Cat# AP18404a
(40 western blots)
Availability: In Stock
Bulk Size
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