|Application ||WB, E|
|Other Accession||Q8R107, NP_037369.1|
|Calculated MW||25181 Da|
|Antigen Region||27-54 aa|
|Other Names||PRELI domain-containing protein 1, mitochondrial, 25 kDa protein of relevant evolutionary and lymphoid interest, Px19-like protein, PRELID1, PRELI|
|Target/Specificity||This PRELID1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-54 amino acids from the N-terminal region of human PRELID1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRELID1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.|
|Cellular Location||Mitochondrion. Mitochondrion intermembrane space|
|Tissue Location||Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
PRELID1 may be important for the development of vital and immunocompetent organs.
Fox, E.J., et al. Biochem. J. 378 (PT 3), 817-825 (2004) :
Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
Guzman-Rojas, L., et al. Int. Immunol. 12(5):607-612(2000)
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