|Application ||WB, E|
|Calculated MW||17419 Da|
|Antigen Region||133-159 aa|
|Other Names||Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, AGTRAP, ATRAP|
|Target/Specificity||This AGTRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human AGTRAP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AGTRAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles|
|Tissue Location||Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
Rabbitts, J.A., et al. J. Physiol. (Lond.) 587 (PT 22), 5441-5449 (2009) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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