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AGTRAP Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP18437b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP18437b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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AGTRAP Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q6RW13 |
| Other Accession | NP_001035284.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 17419 Da |
AGTRAP Antibody (C-term) - Additional info | |
| Gene ID 57085 | |
| Other Names AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein | |
| Target/Specificity This AGTRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-159 amino acids from the C-terminal region of human AGTRAP. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AGTRAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AGTRAP Antibody (C-term) - Protein Information | |
| Name AGTRAP | |
| Synonyms ATRAP | |
| Function Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity | |
| Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles | |
| Tissue Location Ubiquitous but more abundant in kidney, heart, pancreas and thyroid | |
AGTRAP Antibody (C-term) - Related products
AP18437b: AGTRAP Antibody (C-term)
AGTRAP Antibody (C-term) - Application data
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AGTRAP Antibody (C-term) (Cat. #AP18437b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the AGTRAP Antibody detected the AGTRAP protein (arrow).
AGTRAP Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010) Rabbitts, J.A., et al. J. Physiol. (Lond.) 587 (PT 22), 5441-5449 (2009) : Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
