|Application ||WB, E|
|Calculated MW||46936 Da|
|Antigen Region||366-392 aa|
|Other Names||Fc receptor-like protein 1, FcR-like protein 1, FcRL1, Fc receptor homolog 1, FcRH1, IFGP family protein 1, hIFGP1, Immune receptor translocation-associated protein 5, CD307a, FCRL1, FCRH1, IFGP1, IRTA5|
|Target/Specificity||This FCRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-392 amino acids from the C-terminal region of human FCRL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCRL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FCRH1, IFGP1, IRTA5|
|Function||May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kazemi, T., et al. Cancer Immunol. Immunother. 58(6):989-996(2009)
Kazemi, T., et al. Int. J. Cancer 123(9):2113-2119(2008)
Du, X., et al. Blood 111(1):338-343(2008)
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