EXTL1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q92935 |
Other Accession | Q9JKV7, NP_004446.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 74697 Da |
Antigen Region | 649-676 aa |
Gene ID | 2134 |
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Other Names | Exostosin-like 1, Exostosin-L, Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostosis-like protein, EXTL1, EXTL |
Target/Specificity | This EXTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-676 amino acids from the C-terminal region of human EXTL1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | EXTL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EXTL1 |
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Synonyms | EXTL |
Function | Glycosyltransferase required for the biosynthesis of heparan- sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activities (PubMed:11390981). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Mathysen, D., et al. Eur. J. Cancer 40(8):1255-1261(2004)
Zak, B.M., et al. Biochim. Biophys. Acta 1573(3):346-355(2002)
Kim, B.T., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7176-7181(2001)
Xu, L., et al. Hum. Genet. 105 (1-2), 45-50 (1999) :
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