|Application ||WB, E|
|Other Accession||Q9JKV7, NP_004446.2|
|Calculated MW||74697 Da|
|Antigen Region||649-676 aa|
|Other Names||Exostosin-like 1, Exostosin-L, Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostosis-like protein, EXTL1, EXTL|
|Target/Specificity||This EXTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-676 amino acids from the C-terminal region of human EXTL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EXTL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Mathysen, D., et al. Eur. J. Cancer 40(8):1255-1261(2004)
Zak, B.M., et al. Biochim. Biophys. Acta 1573(3):346-355(2002)
Kim, B.T., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7176-7181(2001)
Xu, L., et al. Hum. Genet. 105 (1-2), 45-50 (1999) :
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