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HOXA1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49639 |
| Other Accession | NP_005513.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36641 Da |
| Antigen Region | 9-35 aa |
| Gene ID | 3198 |
|---|---|
| Other Names | Homeobox protein Hox-A1, Homeobox protein Hox-1F, HOXA1, HOX1F |
| Target/Specificity | This HOXA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-35 amino acids from the N-terminal region of human HOXA1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HOXA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HOXA1 |
|---|---|
| Synonyms | HOX1F |
| Function | Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P09022}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
References
Rankin, J.K., et al. J AAPOS 14(1):78-80(2010)
Muscarella, L.A., et al. Mol Autism 1 (1), 9 (2010) :
Canu, E., et al. J Neuroimaging 19(4):353-358(2009)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)
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