|Application ||WB, E|
|Calculated MW||47875 Da|
|Antigen Region||327-355 aa|
|Other Names||Kynurenine--oxoglutarate transaminase 1, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, GTK, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase I, KATI, Kynurenine--oxoglutarate transaminase I, CCBL1|
|Target/Specificity||This CCBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-355 amino acids from the C-terminal region of human CCBL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCBL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
Han, Q., et al. J. Med. Chem. 52(9):2786-2793(2009)
Cooper, A.J., et al. Arch. Biochem. Biophys. 474(1):72-81(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Kapoor, R., et al. Brain Res. 1106(1):205-210(2006)
Cooper, A.J., et al. Amino Acids 30(1):1-15(2006)
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