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ZWILCH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H900 |
| Other Accession | Q8R060, NP_060445.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67214 Da |
| Antigen Region | 482-508 aa |
| Gene ID | 55055 |
|---|---|
| Other Names | Protein zwilch homolog, hZwilch, ZWILCH |
| Target/Specificity | This ZWILCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human ZWILCH. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZWILCH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZWILCH |
|---|---|
| Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). |
| Cellular Location | Chromosome, centromere, kinetochore |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.
References
Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)
Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)
Williams, B.C., et al. Mol. Biol. Cell 14(4):1379-1391(2003)
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