|Application ||WB, E|
|Other Accession||Q8R060, NP_060445.3|
|Calculated MW||67214 Da|
|Antigen Region||482-508 aa|
|Other Names||Protein zwilch homolog, hZwilch, ZWILCH|
|Target/Specificity||This ZWILCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human ZWILCH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZWILCH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).|
|Cellular Location||Chromosome, centromere, kinetochore|
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Provided below are standard protocols that you may find useful for product applications.
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.
Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)
Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)
Williams, B.C., et al. Mol. Biol. Cell 14(4):1379-1391(2003)
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