|Application ||WB, E|
|Calculated MW||40041 Da|
|Antigen Region||91-117 aa|
|Other Names||Beta-1, 4-galactosyltransferase 4, Beta-1, 4-GalTase 4, Beta4Gal-T4, b4Gal-T4, 241-, UDP-Gal:beta-GlcNAc beta-1, 4-galactosyltransferase 4, UDP-galactose:beta-N-acetylglucosamine beta-1, 4-galactosyltransferase 4, N-acetyllactosamine synthase, Nal synthase, Lactotriaosylceramide beta-1, 4-galactosyltransferase, Beta-N-acetylglucosaminyl-glycolipid beta-1, 4-galactosyltransferase, B4GALT4|
|Target/Specificity||This B4GALT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-117 amino acids from the Central region of human B4GALT4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||B4GALT4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack|
|Tissue Location||High expression in heart, placenta, kidney and pancreas; lower in brain, colon, lung, muscle, ovary, testis and uterus|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Guo, S., et al. Glycobiology 11(10):813-820(2001)
Suzuki, Y., et al. Genome Res. 11(5):677-684(2001)
Amado, M., et al. Biochim. Biophys. Acta 1473(1):35-53(1999)
Fan, Y., et al. Sci. China, C, Life Sci. 42(4):337-345(1999)
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