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GNAS Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95467 |
| Other Accession | NP_057676.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28029 Da |
| Antigen Region | 217-244 aa |
| Gene ID | 2778 |
|---|---|
| Other Names | Neuroendocrine secretory protein 55, NESP55, LHAL tetrapeptide, GPIPIRRH peptide, GNAS (HGNC:4392) |
| Target/Specificity | This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the C-terminal region of human GNAS. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNAS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNAS (HGNC:4392) |
|---|---|
| Cellular Location | Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Neuroendocrine secretory granules. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
References
Idziaszczyk, S., et al. Cancer Genet. Cytogenet. 202(1):67-69(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Tominaga, E., et al. Gynecol. Oncol. 118(2):160-166(2010)
Park, C.H., et al. Ann. Clin. Lab. Sci. 40(3):261-266(2010)
Cross, D.S., et al. BMC Genet. 11, 51 (2010) :
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