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HBS1L Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y450 |
| Other Accession | Q6AXM7, Q69ZS7, Q2KHZ2, NP_001138630.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75473 Da |
| Antigen Region | 460-486 aa |
| Gene ID | 10767 |
|---|---|
| Other Names | HBS1-like protein, ERFS, HBS1L, HBS1, KIAA1038 |
| Target/Specificity | This HBS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 460-486 amino acids from the Central region of human HBS1L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HBS1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HBS1L {ECO:0000303|PubMed:28204585, ECO:0000312|HGNC:HGNC:4834} |
|---|---|
| Function | GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:23667253, PubMed:27863242). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:27863242). Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:21448132, PubMed:32006463). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in heart, brain, placenta, liver, muscle, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
References
Nuinoon, M., et al. Hum. Genet. 127(3):303-314(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Nuinoon, M., et al. Hum. Genet. (2009) In press :
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Ferreira, M.A., et al. Am. J. Hum. Genet. 85(5):745-749(2009)
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