|Application ||WB, E|
|Other Accession||Q9GMS6, NP_075563.3|
|Calculated MW||45141 Da|
|Antigen Region||261-289 aa|
|Other Names||Metallophosphoesterase 1, 31--, Post-GPI attachment to proteins factor 5, MPPE1, PGAP5|
|Target/Specificity||This MPPE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human MPPE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPPE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi- pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
Lohoff, F.W., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (3), 830-836 (2010) :
Fujita, M., et al. Cell 139(2):352-365(2009)
Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :
Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :
Vuoristo, J.T., et al. Cytogenet. Cell Genet. 95 (1-2), 60-63 (2001) :
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