|Application ||WB, E|
|Calculated MW||105414 Da|
|Antigen Region||438-465 aa|
|Other Names||TBC1 domain family member 2A, Armus, Prostate antigen recognized and identified by SEREX 1, PARIS-1, TBC1D2, PARIS1, PP8997, TBC1D2A|
|Target/Specificity||This TBC1D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-465 amino acids from the Central region of human TBC1D2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBC1D2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PARIS1, PP8997, TBC1D2A|
|Function||Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Cell junction|
|Tissue Location||Expressed in a broad range of tissues, especially in kidney, liver, lung and placenta. Also expressed in keratinocytes and epithelia-containing organs. Isoform 2 is differentially expressed in prostate normal and cancer cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
TBC1D2 acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivativation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Zhou, Y., et al. Biochem. Biophys. Res. Commun. 290(2):830-838(2002)
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