|Application ||WB, E|
|Calculated MW||180578 Da|
|Antigen Region||1436-1463 aa|
|Other Names||Ras GTPase-activating-like protein IQGAP2, IQGAP2|
|Target/Specificity||This IQGAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1436-1463 amino acids from the C-terminal region of human IQGAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IQGAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.|
|Tissue Location||Isoform 2 expression is enhanced in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Jin, S.H., et al. Int. J. Cancer 122(5):1040-1046(2008)
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