|Application ||WB, E|
|Calculated MW||23256 Da|
|Antigen Region||133-159 aa|
|Other Names||5-formyltetrahydrofolate cyclo-ligase, 10-methenyl-tetrahydrofolate synthetase, MTHFS, Methenyl-THF synthetase, MTHFS|
|Target/Specificity||This MTHFS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human MTHFS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTHFS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate.|
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Provided below are standard protocols that you may find useful for product applications.
MTHFS contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1822-1830(2010)
Hazra, A., et al. Cancer Causes Control 21(3):331-345(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Wu, D., et al. Cancer Res. 69(18):7294-7301(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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