|Application ||WB, E|
|Other Accession||Q8C1S0, NP_703151.1|
|Calculated MW||26273 Da|
|Antigen Region||161-188 aa|
|Other Names||Mediator of RNA polymerase II transcription subunit 19, Lung cancer metastasis-related protein 1, Mediator complex subunit 19, MED19, LCMR1|
|Target/Specificity||This MED19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-188 amino acids from the C-terminal region of human MED19.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MED19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|
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Provided below are standard protocols that you may find useful for product applications.
MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM].
Ding, N., et al. J. Biol. Chem. 284(5):2648-2656(2009)
Sato, S., et al. Mol. Cell 14(5):685-691(2004)
Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)
Sato, S., et al. J. Biol. Chem. 278(17):15123-15127(2003)
Reddy, P.H., et al. Genomics 46(2):174-182(1997)
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