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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   MRPL40 Antibody (C-term)   

MRPL40 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MRPL40 Antibody (C-term) AP18646b
    MRPL40 Antibody (C-term) (Cat. #AP18646b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the MRPL40 antibody detected the MRPL40 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NQ50
Other Accession NP_003767.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 172-200 aa
Additional Information
Other Names 39S ribosomal protein L40, mitochondrial, L40mt, MRP-L40, Nuclear localization signal-containing protein deleted in velocardiofacial syndrome, Up-regulated in metastasis, MRPL40, NLVCF, URIM
Target/Specificity This MRPL40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human MRPL40.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMRPL40 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRPL40
Synonyms NLVCF, URIM
Cellular Location Mitochondrion
Tissue Location Ubiquitous.. EMBL; AF034091; AAC70904.1; -; mRNA EMBL; AJ295637; CAC00535.1; -; mRNA EMBL; CR456532; CAG30418.1; -; mRNA EMBL; AK123768; BAG53959.1; -; mRNA EMBL; CH471176; EAX03042.1; -; Genomic_DNA EMBL; BC009707; AAH09707.1; -; mRNA CCDS; CCDS13760.1; - RefSeq; NP_003767.2; NM_003776.3 UniGene; Hs.431307; - PDB; 3J7Y; EM; 3.40 A; 8=1-206 PDB; 3J9M; EM; 3.50 A; 8=1-206 PDBsum; 3J7Y; - PDBsum; 3J9M; - ProteinModelPortal; Q9NQ50; - SMR; Q9NQ50; - BioGrid; 122364; 69 IntAct; Q9NQ50; 15 MINT; MINT-6782189; - STRING; 9606.ENSP00000333401; - iPTMnet; Q9NQ50; - PhosphoSitePlus; Q9NQ50; - BioMuta; MRPL40; - DMDM; 21263795; - EPD; Q9NQ50; - MaxQB; Q9NQ50; - PaxDb; Q9NQ50; - PeptideAtlas; Q9NQ50; - PRIDE; Q9NQ50; - TopDownProteomics; Q9NQ50; - DNASU; 64976; - Ensembl; ENST00000333130; ENSP00000333401; ENSG00000185608 GeneID; 64976; - KEGG; hsa:64976; - UCSC; uc002zpg.4; human CTD; 64976; - DisGeNET; 64976; - GeneCards; MRPL40; - HGNC; HGNC:14491; MRPL40 HPA; HPA006181; - MIM; 605089; gene neXtProt; NX_Q9NQ50; - OpenTargets; ENSG00000185608; - PharmGKB; PA30972; - eggNOG; KOG4778; Eukaryota eggNOG; ENOG4111PQW; LUCA GeneTree; ENSGT00390000010239; - HOGENOM; HOG000015976; - HOVERGEN; HBG044505; - InParanoid; Q9NQ50; - KO; K17421; - OMA; RCLHTTP; - OrthoDB; EOG091G0RI9; - PhylomeDB; Q9NQ50; - TreeFam; TF105982; - BioCyc; ZFISH:G66-33484-MONOMER; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination GeneWiki; MRPL40; - GenomeRNAi; 64976; - PRO; PR:Q9NQ50; - Proteomes; UP000005640; Chromosome 22 Bgee; ENSG00000185608; - CleanEx; HS_MRPL40; - Genevisible; Q9NQ50; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0005634; C:nucleus; TAS:ProtInc GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome InterPro; IPR019192; Ribosomal_L28/L40_mit Pfam; PF09812; MRP-L28; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 46 Mitochondrion {ECO:0000250|UniProtKB:P83565} CHAIN 47 206 39S ribosomal protein L40, mitochondrial /FTId=PRO_0000030558 VARIANT 11 11 L -> P (in dbSNP:rs1128399) /FTId=VAR_061809 VARIANT 129 129 R -> H (in dbSNP:rs7575) /FTId=VAR_016088 SEQUENCE 206 AA; 24490 MW; AE6262A9A94B05FD CRC64; MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFIT PLKFLDKARE RPQVELTFEE TERRALLLKK WSLYKQQERK MERDTIRAML EAQQEALEEL QLESPKLHAE AIKRDPNLFP FEKEGPHYTP PIPNYQPPEG RYNDITKVYT QVEFKR
Research Areas
Citations (0)

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Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.

References

Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Zhang, Z., et al. Genomics 81(5):468-480(2003)
Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :
Hildebrandt, T., et al. Anticancer Res. 19 (1A), 525-530 (1999) :
Goldschmidt-Reisin, S., et al. J. Biol. Chem. 273(52):34828-34836(1998)

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$ 295.00
$ 99.00
Cat# AP18646b
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Quantity:
(40 western blots)
Availability: In Stock
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