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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ACER1 Antibody (C-term)   

ACER1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ACER1 Antibody (C-term) AP18654b
    ACER1 Antibody (C-term) (Cat. #AP18654b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ACER1 antibody detected the ACER1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDN7
Other Accession NP_597999.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31095 Da
Antigen Region 236-263 aa
Additional Information
Gene ID 125981
Other Names Alkaline ceramidase 1, AlkCDase 1, Alkaline CDase 1, Acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ACER1, ASAH3
Target/Specificity This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACER1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACER1
Synonyms ASAH3
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Mainly expressed in epidermis.
Research Areas
Citations (0)

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Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).


Sun, W., et al. J. Invest. Dermatol. 128(2):389-397(2008)
Toulza, E., et al. Genome Biol. 8 (6), R107 (2007) :
Houben, E., et al. J. Lipid Res. 47(5):1063-1070(2006)
Mao, C., et al. J. Biol. Chem. 278(33):31184-31191(2003)
Ito, M., et al. Tanpakushitsu Kakusan Koso 47 (4 SUPPL), 455-462 (2002) :

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$ 295.00
$ 99.00
Cat# AP18654b
(40 western blots)
Availability: In Stock
Bulk Size
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