|Application ||WB, E|
|Calculated MW||114874 Da|
|Antigen Region||596-622 aa|
|Other Names||Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor, Apolipoprotein B48 receptor, apoB-48R, APOBR, APOB48R|
|Target/Specificity||This APOB48R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596-622 amino acids from the Central region of human APOB48R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APOB48R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.|
|Cellular Location||Cell membrane; Peripheral membrane protein Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein|
|Tissue Location||Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells|
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Provided below are standard protocols that you may find useful for product applications.
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq].
Kawakami, A., et al. Arterioscler. Thromb. Vasc. Biol. 25(2):424-429(2005)
Fujita, Y., et al. J. Hum. Genet. 50(4):203-209(2005)
Brown, M.L., et al. Proc. Natl. Acad. Sci. U.S.A. 97(13):7488-7493(2000)
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