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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   APOB48R Antibody (Center)   

APOB48R Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - APOB48R Antibody (Center) AP18657c
    APOB48R Antibody (Center) (Cat. #AP18657c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the APOB48R antibody detected the APOB48R protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q0VD83
Other Accession NP_061160.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 114874 Da
Antigen Region 596-622 aa
Additional Information
Gene ID 55911
Other Names Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor, Apolipoprotein B48 receptor, apoB-48R, APOBR, APOB48R
Target/Specificity This APOB48R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 596-622 amino acids from the Central region of human APOB48R.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPOB48R Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APOB48R
Function Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
Cellular Location Cell membrane; Peripheral membrane protein Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein
Tissue Location Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells
Research Areas
Citations (0)

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Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq].


Kawakami, A., et al. Arterioscler. Thromb. Vasc. Biol. 25(2):424-429(2005)
Fujita, Y., et al. J. Hum. Genet. 50(4):203-209(2005)
Brown, M.L., et al. Proc. Natl. Acad. Sci. U.S.A. 97(13):7488-7493(2000)

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$ 295.00
$ 99.00
Cat# AP18657c
(40 western blots)
Availability: In Stock
Bulk Size
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