|Application ||WB, E|
|Calculated MW||80698 Da|
|Antigen Region||132-158 aa|
|Other Names||Calcium-responsive transcription factor, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein, Calcium-response factor, CaRF, Testis development protein NYD-SP24, CARF, ALS2CR8|
|Target/Specificity||This ALS2CR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-158 amino acids from the N-terminal region of human ALS2CR8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALS2CR8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence.|
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Provided below are standard protocols that you may find useful for product applications.
ALS2CR8 may be a transcription factor (By similarity).
Cheung, C.T., et al. Mech. Ageing Dev. 130 (1-2), 18-23 (2009) :
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Hasan, M.K., et al. J. Biol. Chem. 277(40):37765-37770(2002)
Tao, X., et al. Neuron 33(3):383-395(2002)
Hadano, S., et al. Nat. Genet. 29(2):166-173(2001)
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