|Application ||WB, E|
|Calculated MW||44967 Da|
|Antigen Region||82-108 aa|
|Other Names||Transcription factor Dp family member 3, Cancer/testis antigen 30, CT30, Hepatocellular carcinoma-associated antigen 661, TFDP3, DP4, HCA661|
|Target/Specificity||This TFDP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human TFDP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFDP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.|
|Cellular Location||Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members|
|Tissue Location||Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
Tian, C., et al. Biochem. Biophys. Res. Commun. 361(1):20-25(2007)
Qiao, H., et al. J. Biol. Chem. 282(1):454-466(2007)
Milton, A., et al. Oncogene 25(22):3212-3218(2006)
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