|Application ||WB, E|
|Other Accession||Q9QZN3, Q5E9G6, NP_036312.2|
|Calculated MW||37068 Da|
|Antigen Region||168-195 aa|
|Other Names||F-box only protein 8, F-box/SEC7 protein FBS, FBXO8, FBS, FBX8|
|Target/Specificity||This FBXO8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the Central region of human FBXO8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXO8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity.
Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Ilyin, G.P., et al. Genomics 67(1):40-47(2000)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
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