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RPA4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RPA4 Antibody (C-term) AP18746b
    RPA4 Antibody (C-term)(Cat. #AP18746b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the RPA4 antibody detected the RPA4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13156
Other Accession NP_037479.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28868 Da
Antigen Region 234-261 aa
Additional Information
Gene ID 29935
Other Names Replication protein A 30 kDa subunit, RP-A p30, Replication factor A protein 4, RF-A protein 4, RPA4
Target/Specificity This RPA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-261 amino acids from the C-terminal region of human RPA4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRPA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPA4
Function As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Cellular Location Nucleus. Note=Localizes to DNA repair foci after DNA damage
Tissue Location Preferentially expressed in placental and colon mucosa. Widely expressed at intermediate or lower levels
Citations (0)

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This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.


Kemp, M.G., et al. J. Biol. Chem. 285(7):4788-4797(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Haring, S.J., et al. Nucleic Acids Res. 38(3):846-858(2010)
Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)
Mason, A.C., et al. J. Biol. Chem. 284(8):5324-5331(2009)

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$ 295.00
$ 99.00
Cat# AP18746b
(40 western blots)
Availability: In Stock
Bulk Size
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