|Application ||WB, E|
|Calculated MW||86351 Da|
|Antigen Region||711-739 aa|
|Other Names||Kazrin, KAZN, KAZ, KIAA1026|
|Target/Specificity||This KAZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 711-739 amino acids from the C-terminal region of human KAZ.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KAZ Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.|
|Cellular Location||Cytoplasm, cytoskeleton. Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane Colocalizes with cortical actin-based membrane structures|
|Tissue Location||Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nachat, R., et al. J. Cell. Sci. 122 (PT 22), 4035-4041 (2009) :
Wang, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(9):763-772(2009)
Sevilla, L.M., et al. J. Cell. Sci. 121 (PT 21), 3561-3569 (2008) :
Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)
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