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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CRADD Antibody (Center)   

CRADD Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CRADD Antibody (Center) AP18802C
    CRADD Antibody (Center)(Cat. #AP18802c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the CRADD antibody detected the CRADD protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78560
Other Accession NP_003796.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22745 Da
Antigen Region 69-98 aa
Additional Information
Gene ID 8738
Other Names Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD
Target/Specificity This CRADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the Central region of human CRADD.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRADD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RAIDD
Function Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
Cellular Location Cytoplasm. Nucleus
Tissue Location Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney
Research Areas
Citations (0)

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The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Jang, T.H., et al. Biochim. Biophys. Acta 1804(7):1557-1563(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Heikaus, S., et al. Cell. Oncol. 32 (1-2), 29-42 (2010) :

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$ 295.00
$ 99.00
Cat# AP18802C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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