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API5 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP18825b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP18825b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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- Backgrounds
API5 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9BZZ5 |
| Other Accession | NP_006586.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 59005 Da |
API5 Antibody (C-term) - Additional info | |
| Gene ID 8539 | |
| Other Names API5; Apoptosis inhibitor 5; Antiapoptosis clone 11 protein; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; Protein XAGL | |
| Target/Specificity This API5 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 481-510 amino acids selected from the C-terminal region of human API5. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions API5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
API5 Antibody (C-term) - Protein Information | |
| Name API5 | |
| Function Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs | |
| Cellular Location Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic | |
| Tissue Location Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer | |
API5 Antibody (C-term) - Related products
API5 Antibody (C-term) - Application data
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API5 Antibody (C-term)(Cat. #AP18825b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the API5 antibody detected the API5 protein (arrow).
API5 Antibody (C-term) - Research Areas
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BACKGROUND
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
REFERENCES
Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) : Ren, K., et al. Pathol. Oncol. Res. 16(2):229-237(2010) Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009) Rigou, P., et al. EMBO J. 28(11):1576-1588(2009) Wang, Y., et al. J. Biol. Chem. 283(19):13205-13215(2008)
